One important therapy module which I would like to emphasize here is the Bladder-Instillation Therapy with Hyaluronate, a substance which mimics the bladder mucus.
This therapy was devised in the early 1990s under the pretext to find a substance that can help to avoid the attachment of bacteria at the bladder wall.
The so-called GAG-layer was found, a mucus-like substance which clads the bladder from inside, and indeed hinders adherence of bacteria.
In the following years it was shown that women with recurrent bladder inflammations and with ISC often have a GAG-deficiency.
Several substances have been found which can replace the deficient GAG-layer and the application via catheter provides a highly efficient therapy without distribution over the bloodstream.
In other words, the therapeutic substance is instilled into the bladder with a little catheter (which will be removed immediately after the application) and does not need to travel through the whole gastro-intestinal – and bloodstream-system in order to reach finally the organ of interest which is the bladder.